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Anti-LPCAT2 Antibody (CAB4805)

SKU:
CAB4805
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
LPCAT2
AGPAT11
AYTL1
LysoPAFAT
Research Area:
Metabolism
  • Metabolism Antibodies 2 Anti-LPCAT2 Antibody CAB4805
  • Metabolism Antibodies 2 Anti-LPCAT2 Antibody CAB4805
€139 - €419
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Description

Product Name:LPCAT2 Rabbit pAb
Product Code:CAB4805
Size:20uL, 50uL, 100uL
Synonyms:LPCAT2, AGPAT11, AYTL1, LysoPAFAT
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-544 of human LPCAT2 (NP_060309.2).
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:HeLa, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 160-544 of human LPCAT2 (NP_060309.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LPSM VSRN ENAQ VPLI GRLL RAVQ PVLV SRVD PDSR KNTI NEII KRTT SGGE WPQI LVFP EGTC TNRS CLIT FKPG AFIP GVPV QPVL LRYP NKLD TVTW TWQG YTFI QLCM LTFC QLFT KVEV EFMP VQVP NDEE KNDP VLFA NKVR NLMA EALG IPVT DHTY EDCR LMIS AGQL TLPM EAGL VEFT KISR KLKL DWDG VRKH LDEY ASIA SSSK GGRI GIEE FAKY LKLP VSDV LRQL FALF DRNH DGSI DFRE YVIG LAVL CNPS NTEE IIQV AFKL FDVD EDGY ITEE EFST ILQA SLGV PDLD VSGL FKEI AQGD SISY EEFK SFAL KHPE YAKI FTTY LDLQ TCHV FSLP KEVQ TTPS TASN KVSP EKHE ESTS DKKD D
Gene ID:54947
Uniprot:Q7L5N7
Cellular Location:Endoplasmic reticulum membrane, Golgi apparatus membrane, Lipid droplet, Single-pass type II membrane protein
Calculated MW:30kDa/60kDa
Observed MW:52kDa
UniProt Protein Function:AYTL1: Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet- activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso- PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-alkyl-phosphatidylcholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.3.1.23; EC 2.3.1.67; Acetyltransferase; Membrane protein, integral; EC 2.3.1.51

Chromosomal Location of Human Ortholog: 16q12.2

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; Golgi stack; endoplasmic reticulum; integral to membrane; lipid particle

Molecular Function:1-alkylglycerophosphocholine O-acetyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; calcium ion binding; 1-acylglycerol-3-phosphate O-acyltransferase activity

Biological Process: platelet activating factor biosynthetic process; phospholipid metabolic process; glycerophospholipid biosynthetic process

NCBI Summary:This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]
UniProt Code:Q7L5N7
NCBI GenInfo Identifier:74738601
NCBI Gene ID:54947
NCBI Accession:Q7L5N7.1
UniProt Secondary Accession:Q7L5N7,Q6MZJ6, Q9NX23, A3KBM1,
UniProt Related Accession:Q7L5N7
Molecular Weight:544
NCBI Full Name:Lysophosphatidylcholine acyltransferase 2
NCBI Synonym Full Names:lysophosphatidylcholine acyltransferase 2
NCBI Official Symbol:LPCAT2  
NCBI Official Synonym Symbols:AYTL1; LysoPAFAT  
NCBI Protein Information:lysophosphatidylcholine acyltransferase 2; LPCAT-2; 1-AGPAT 11; LPAAT-alpha; LPC acyltransferase 2; acyltransferase like 1; acyltransferase-like 1; 1-AGP acyltransferase 11; lysoPC acyltransferase 2; lyso-PAF acetyltransferase; acetyl-CoA:lyso-PAF acetyltransferase; lysophosphatidic acid acyltransferase alpha; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-alkylglycerophosphocholine O-acetyltransferase; acyl-CoA:lysophosphatidylcholine acyltransferase 2; lyso-platelet-activating factor (PAF) acetyltransferase; acetyl-CoA:lyso-platelet-activating factor acetyltransferase
UniProt Protein Name:Lysophosphatidylcholine acyltransferase 2
UniProt Synonym Protein Names:1-acylglycerol-3-phosphate O-acyltransferase 11 (EC:2.3.1.51); 1-AGP acyltransferase 11; 1-AGPAT 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acetyl-CoA:lyso-PAF acetyltransferase; Lyso-PAF acetyltransferase; LysoPAFAT; Acyltransferase-like 1; Lysophosphatidic acid acyltransferase alpha; LPAAT-alpha
Protein Family:Lysophosphatidylcholine acyltransferase
UniProt Gene Name:LPCAT2  
UniProt Entry Name:PCAT2_HUMAN

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