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Anti-MAS1 Antibody (CAB8132)

SKU:
CAB8132
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 3 Anti-MAS1 Antibody CAB8132
  • Signal Transduction Antibodies 3 Anti-MAS1 Antibody CAB8132
€139 - €419
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Description

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Antibody Name:MAS1 Rabbit Polyclonal Antibody
Antibody SKU:CAB8132
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 246-325 of human MAS1 (NP_002368.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HepG2, A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 246-325 of human MAS1 (NP_002368.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LLYL LYYE YWST FGNL HHIS LLFS TINS SANP FIYF FVGS SKKK RFKE SLKV VLTR AFKD EMQP RRQK DNCN TVTV ETVV
Gene ID:4142
Uniprot:P04201
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:37kDa
Observed MW:41kDa
Synonyms:MAS1, MAS, MGRA
Background:This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7).
UniProt Protein Function:MAS1: Receptor for angiotensin 1-7. Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. The MAS oncogene has a weak focus-inducing activity in transfected NIH 3T3 cells. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Oncoprotein; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6q25.3-q26

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:angiotensin receptor activity; angiotensin type II receptor activity; G-protein coupled receptor activity; peptide binding; protein binding

Biological Process: anatomical structure morphogenesis; cell proliferation; G-protein coupled receptor protein signaling pathway

NCBI Summary:This gene encodes a class I seven-transmembrane G-protein-coupled receptor. The encoded protein is a receptor for angiotensin-(1-7) and preferentially couples to the Gq protein, activating the phospholipase C signaling pathway. The encoded protein may play a role in multiple processes including hypotension, smooth muscle relaxation and cardioprotection by mediating the effects of angiotensin-(1-7). [provided by RefSeq, May 2012]
UniProt Code:P04201
NCBI GenInfo Identifier:135920
NCBI Gene ID:4142
NCBI Accession:P04201.1
UniProt Secondary Accession:P04201,Q2TBC9, Q6FG47, E1P5B3,
UniProt Related Accession:P04201
Molecular Weight:37,465 Da
NCBI Full Name:Proto-oncogene Mas
NCBI Synonym Full Names:MAS1 proto-oncogene, G protein-coupled receptor
NCBI Official Symbol:MAS1  
NCBI Official Synonym Symbols:MAS; MGRA  
NCBI Protein Information:proto-oncogene Mas
UniProt Protein Name:Proto-oncogene Mas
Protein Family:Proto-oncogene
UniProt Gene Name:MAS1  
UniProt Entry Name:MAS_HUMAN
Anti-MAS1 Polyclonal Antibody (CAB8132)Western blot analysis of extracts of various cell lines, using MAS1 antibody (CAB8132) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-MAS1 Polyclonal Antibody (CAB8132)Immunohistochemistry of paraffin-embedded mouse kidney using MAS1 antibody (CAB8132) at dilution of 1:100 (40x lens).

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