NOS3 Polyclonal Antibody (AGEL2142)
- SKU:
- AGEL2142
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Application:
- ELISA
Frequently bought together:
Description
| Antibody Name: | NOS3 Polyclonal Antibody |
| Antibody Code: | AGEL2142 |
| Size: | 120 µL |
| Immunogen: | Synthesized peptide derived from human NOS3 around the non-phosphorylation site of Ser1177. |
| Synonyms: | cNOS,Constitutive NOS, NOS 3,NOS III,NOS type III |
| Species Reactivity: | Human, Rat, Mouse, Monkey, Dog, Chicken, Hamster, Rabbit, Sheep, Pig, Zebrafish, Xenopus, Cow |
| Applications: | WB, IHC, IF, ELISA |
| Concentration: | 1mg/mL |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Applications: | WB, IHC, IF, ELISA |
| Recommended Dilution: |
WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:40000 |
| Storage Buffer: | PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4 |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. |
| Uniprot: | P29474 |
| Calculated MW: | 133kDa |
| Observed MW: | 140kDa |
| Background: | Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. |
| Cellular Localization: | Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle and which is favored by interaction with NOSIP and results in a reduced enzymatic activity. |
| Tissue Specificity: | Platelets, placenta, liver and kidney. |
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