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Anti-PPP2R5A Antibody (CAB15706)

SKU:
CAB15706
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
€139 - €419
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Description

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Antibody Name:Anti-PPP2R5A Antibody
Antibody SKU:CAB15706
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-130 of human PPP2R5A (NP_006234.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:MCF7, U-87MG, LO2, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 50-130 of human PPP2R5A (NP_006234.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QAEL HPLP QLKD ATSN EQQE LFCQ KLQQ CCIL FDFM DSVS DLKS KEIK RATL NELV EYVS TNRG VIVE SAYS DIVK MISA N
Gene ID:5525
Uniprot:Q15172
Cellular Location:Chromosome, Cytoplasm, Nucleus, centromere
Calculated MW:50kDa/56kDa
Observed MW:56kDa
Synonyms:PPP2R5A, B56A, PR61A, B56alpha
Background:The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene.
UniProt Protein Function:PPP2R5A: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein phosphatase, regulatory subunit; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q32.2-q32.3

Cellular Component: protein phosphatase type 2A complex; membrane; cytoplasm; M band; Z disc; nucleus; chromosome, pericentric region

Molecular Function:protein binding; protein phosphatase type 2A regulator activity; kinase binding

Biological Process: signal transduction; positive regulation of protein amino acid dephosphorylation

NCBI Summary:The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q15172
NCBI GenInfo Identifier:7387496
NCBI Gene ID:5525
NCBI Accession:Q15172.1
UniProt Secondary Accession:Q15172,Q2NL72, Q5VVB2, Q8TBI9, B2R6D2, B7Z7L2, D3DT99
UniProt Related Accession:Q15172
Molecular Weight:486
NCBI Full Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
NCBI Synonym Full Names:protein phosphatase 2, regulatory subunit B', alpha
NCBI Official Symbol:PPP2R5A  
NCBI Official Synonym Symbols:B56A; PR61A  
NCBI Protein Information:serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform; PR61alpha; PP2A B subunit isoform B'-alpha; PP2A B subunit isoform R5-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PP2A, B subunit, B' alpha isoform; PP2A, B subunit, R5 alpha isoform; PP2A, B subunit, B56 alpha isoform; PP2A, B subunit, PR61 alpha isoform; protein phosphatase 2, regulatory subunit B', alpha isoform; protein phosphatase 2, regulatory subunit B (B56), alpha isoform; serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform
UniProt Protein Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
UniProt Synonym Protein Names:PP2A B subunit isoform B'-alpha; PP2A B subunit isoform B56-alpha; PP2A B subunit isoform PR61-alpha; PR61alpha; PP2A B subunit isoform R5-alpha
Protein Family:Serine/threonine-protein phosphatase
UniProt Gene Name:PPP2R5A  
UniProt Entry Name:2A5A_HUMAN
Anti-PPP2R5A Antibody (CAB15706)Western blot analysis of extracts of various cell lines, using PPP2R5A antibody (CAB15706) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

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