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Anti-TCTN3 Antibody (CAB0684)

SKU:
CAB0684
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Death
  • Cell Death Antibodies 1 Anti-TCTN3 Antibody CAB0684
  • Cell Death Antibodies 1 Anti-TCTN3 Antibody CAB0684
€139 - €419
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Description

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Antibody Name:Anti-TCTN3 Antibody
Antibody SKU:CAB0684
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-475 of human TCTN3 (NP_056446.4).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:Mouse craniofacial, Mouse lung, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 200-475 of human TCTN3 (NP_056446.4).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:QTQS PPSF YRAG DPIL TYFP KWSV ISLL RQPA GVGA GGLC AESN PAGF LESK STTC TRFF KNLA SSCT LDSA LNAA SYYN FTVL KVPR SMTD PQNM EFQV PVIL TSQA NAPL LAGN TCQN VVSQ VTYE IETN GTFG IQKV SVSL GQTN LTVE PGAS LQQH FILR FRAF QQST AASL TSPR SGNP GYIV GKPL LALT DDIS YSMT LLQS QGNG SCSV KRHE VQFG VNAI SGCK LRLK KADC SHLQ QEIY QTLH GRPR PEYV AIFG NADP AQKG GWTR
Gene ID:26123
Uniprot:Q6NUS6
Cellular Location:Membrane, Single-pass type I membrane protein
Calculated MW:22kDa/47kDa/50kDa/66kDa
Observed MW:68kDa
Synonyms:TCTN3, C10orf61, JBTS18, OFD4, TECT3
Background:This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
UniProt Protein Function:TCTN3: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. May be involved in apoptosis regulation. Belongs to the tectonic family. 5 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q24.1

Cellular Component: integral to membrane

Biological Process: smoothened signaling pathway; apoptosis; organelle organization and biogenesis

Disease: Joubert Syndrome 18; Joubert Syndrome 1; Orofaciodigital Syndrome Iv

NCBI Summary:This gene encodes a member of the tectonic gene family which functions in Hedgehog signal transduction and development of the neural tube. Mutations in this gene have been associated with Orofaciodigital Syndrome IV and Joubert Syndrom 18. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]
UniProt Code:Q6NUS6
NCBI GenInfo Identifier:91208025
NCBI Gene ID:26123
NCBI Accession:Q6NUS6.2
UniProt Secondary Accession:Q6NUS6,Q6P7P3, Q6UW27, Q6ZQQ0, Q8N7K1, Q8NBQ0, Q96GF7 Q9Y3U1, A6NIC8, B0QZ90, B4DR81,
UniProt Related Accession:Q6NUS6
Molecular Weight:607
NCBI Full Name:Tectonic-3
NCBI Synonym Full Names:tectonic family member 3
NCBI Official Symbol:TCTN3  
NCBI Official Synonym Symbols:OFD4; TECT3; JBTS18; C10orf61  
NCBI Protein Information:tectonic-3
UniProt Protein Name:Tectonic-3
Protein Family:Tectonic
UniProt Gene Name:TCTN3  
UniProt Entry Name:TECT3_HUMAN
Anti-TCTN3 Antibody (CAB0684)Western blot analysis of extracts of various cell lines, using TCTN3 antibody (CAB0684) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Anti-TCTN3 Antibody (CAB0684)Immunohistochemistry of paraffin-embedded human liver cancer using TCTN3 antibody (CAB0684) at dilution of 1:100 (40x lens).

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