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Anti-TSPYL1 Antibody (CAB12174)

SKU:
CAB12174
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 2 Anti-TSPYL1 Antibody CAB12174
  • Cell Biology Antibodies 2 Anti-TSPYL1 Antibody CAB12174
€139 - €419
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Description

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Antibody Name:Anti-TSPYL1 Antibody
Antibody SKU:CAB12174
Antibody Size:20uL, 50uL, 100uL
Application:WB IP
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human TSPYL1 (NP_003300.1).
Application:WB IP
Recommended Dilution:WB 1:500 - 1:2000 IP 1:50 - 1:100
Reactivity:Human
Positive Samples:U-87MG, SKOV3, LO2, HeLa, 293T, A-549
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human TSPYL1 (NP_003300.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSGL DGVK RTTP LQTH SIII SDQV PSDQ DAHQ YLRL RDQS EATQ VMAE PGEG GSET VALP PPPP SEEG GVPQ DAAG RGGT PQIR VVGG RGHV AIKA GQEE GQPP AEGL AAAS VVMA ADRS LKKG VQGG EKAL EICG AQRS ASEL TAGA EAEA EEVK TGKC ATVS AAVA ERES AEVV KEGL AEKE VMEE QMEV EEQP PEGE EIEV AEED RLEE EARE EEGP WPLH EALR MD
Gene ID:7259
Uniprot:Q9H0U9
Cellular Location:Nucleus, nucleolus
Calculated MW:49kDa
Observed MW:60kDa
Synonyms:TSPYL1, TSPYL
Background:The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT).
UniProt Protein Function:TSPYL1: Defects in TSPYL1 are the cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). SIDDT is an autosomal recessive disorder. Affected infants appear normal at birth, develop signs of visceroautonomic dysfunction early in life, and die before 12 months of age of abrupt cardiorespiratory arrest. Features included bradycardia, hypothermia, severe gastroesophageal reflux, laryngospasm, bronchospasm, and abnormal cardiorespiratory patterns during sleep. Genotypic males with SIDDT had fetal testicular dysgenesis and ambiguous genitalia, with findings such as intraabdominal testes, dysplastic testes, deficient fetal testosterone production, fusion and rugation of the gonadal sac, and partial development of the penile shaft. Female sexual development was normal. Affected infants had an unusual staccato cry, similar to the cry of a goat. Belongs to the nucleosome assembly protein (NAP) family.
UniProt Protein Details:

Protein type:Nucleolus

Chromosomal Location of Human Ortholog: 6q22.1

Cellular Component: nucleolus; nucleus

Molecular Function:enzyme binding

Disease: Sudden Infant Death With Dysgenesis Of The Testes Syndrome

NCBI Summary:The protein encoded by this gene is found in the nucleolus and is similar to that of a family of genes on the Y-chromosome. This gene is intronless. Defects in this gene are a cause of sudden infant death with dysgenesis of the testes syndrome (SIDDT). [provided by RefSeq, Dec 2009]
UniProt Code:Q9H0U9
NCBI GenInfo Identifier:209572711
NCBI Gene ID:7259
NCBI Accession:Q9H0U9.3
UniProt Secondary Accession:Q9H0U9,O75885, Q5TFE6,
UniProt Related Accession:Q9H0U9
Molecular Weight:49kDa
NCBI Full Name:Testis-specific Y-encoded-like protein 1
NCBI Synonym Full Names:TSPY like 1
NCBI Official Symbol:TSPYL1  
NCBI Official Synonym Symbols:TSPYL  
NCBI Protein Information:testis-specific Y-encoded-like protein 1
UniProt Protein Name:Testis-specific Y-encoded-like protein 1
Protein Family:Testis-specific Y-encoded-like protein
UniProt Gene Name:TSPYL1  
Anti-TSPYL1 Antibody (CAB12174)Western blot analysis of extracts of various cell lines, using TSPYL1 antibody (CAB12174) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 3s.
Anti-TSPYL1 Antibody (CAB12174)Immunoprecipitation analysis of 200ug extracts of HeLa cells, using 3 ug TSPYL1 antibody (CAB12174). Western blot was performed from the immunoprecipitate using TSPYL1 antibody (CAB12174) at a dilition of 1:1000.

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